BIO-DISC

 

Nano-structured bioactive small diameter vascular graft

 

The Israel – Germany BIO-DISC program
Project's number / Office of the Chief Scientist: 48967

 

The project main goal is to develop a non-occluding, highly hemocompatible small diameter electrospun vascular graft coated with bio-molecules, which will induce endothelialisation following implantation.

 

The new graft is designed to address a significant unmet need in the coronary artery disease (CAD) field. In addition, the project includes intermediate stage in which medium diameter graft, intended to be used for peripheral vascular disease (PVD), will be developed.

To project is based on collaboration between Nicast, a German company, Hemoteq AG, and the University of Tubingen (UKT). Based on Nicast's experience in electrospinning technology and in launching the first electrospun vascular access graft, a medium (>5 mm) and small (3mm) diameter electrospun vascular grafts, which are the scaffold onto which the coatings will be applied, are being developed.

 

Hemoteq's team is developing method and technology for coating the lumen of the electrospun graft with biomolecules, based on Hemoteq’s CamouflageTM hemocompatible coating technology. UKT contribution is led by Prof. Hans Wendel, a recognized expert in the field of hemocompatibility of blood-contacting biomaterials. UKT provides the endothelialisation inducer factor, scientific support and know-how for in vivo tissue engineering of vascular grafts, and testing capabilities for characterization of the interaction between vascular grafts and blood.

 

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